A man struggling with his faith is haunted by the sins of his past but is suddenly thrust into the role of defending humanity from the gathering forces of darkness.
A message from a deceased friend sends exorcist John Constantine to Atlanta to help the man's daughter, Liv. A demon is trying to kill her, and Constantine must face the powers of darkness to save her life. Meanwhile, the forces of Heaven try to recruit Constantine to their cause... whether he wants to join them or not.
Using Liv's map, Constantine learns of a series of strange deaths in the Pennsylvania mining town of Heddwich. There he finds a woman, Zed Martin, who is drawn to him by visions that she can't explain.
Constantine investigates the death of an old friend and discovers that he was involved in the hunt for the Devil's Vinyl: a 45 LP that has recorded the Devil's voice and brings doom to anyone who touches it
A survivor from the Newcastle exorcism comes to Atlanta, seeking atonement but leaving death and destruction in his path. John soon discovers the reason why and must decide what he is willing to sacrifice to put an end to the demonic events.
The scry map leads Constantine, Chas, and Zed to New Orleans to investigate the bizarre death of a woman at the hands of a masked ghost. Constantine soon discovers other victims and a common denominator: Papa Midnite.
A series of brutal murders leads Constantine to a spirit that jumps from child to child, killing the parents... and the spirit now occupies a new host and is preparing to murder again.
The scry map and Zed's visions lead her and Constantine to a preacher who has gained the power to grant healing miracles... at a terrible cost.
A Newcastle survivor calls Constantine to a convent in Mexico City to investigate the supernatural abduction of a baby and the murder of his mother. Meanwhile, Zed goes out and meets Eddie again.
To help free Constantine from the demon that has possessed him, Chas, Zed, and Anne Marie have to break into a Mexican prison and help him escape.
A mystical force steals the souls from thousands of New Yorkers... including Chas' daughter. He turns to Constantine for help, but when his friend fails, Chas makes a deal with the sorcerer responsible.
Manny sends Constantine to help Ritchie, one of the Newcastle crew, when four students inadvertently make themselves the target of a vicious killer who can pull them into his world.
Manny is forced to learn humanity when Constantine traps him in a host body to force his cooperation in investigating a murder. Meanwhile, Zed learns that her visions have a physiological cause... which may be killing her.
Constance and Zed return to New Orleans to help Jim Corrigan investigate the case of a missing girl... and the police officer who died trying to find her. Meanwhile, Papa Midnite sets out to collect a bounty on Constantine's head, and Manny contacts Zed.
