
Wilbur Post and his wife Carol move into a beautiful new home. When Wilbur takes a look in his new barn, he finds that the former owner left his horse behind. This horse is no ordinary horse . . . he can talk, but only to Wilbur, which leads to all sorts of misadventures for Wilbur and his trouble-making sidekick Mister Ed.



Newlyweds Carol and Wilbur Post move into their first home. When they discover that the previous owner left their horse in the barn out back, Carol suggest that they sell him. Wilbur however, convinces her to keep him and soon discovers that Mister Ed has a big secret.
Mister Ed decides that it's time for him to go to medical school in order to become a "Palomino Horse Doctor" – P.H.D.