
Masane Amaha and her daughter Rihoko are on the run from a government child welfare agency that wants to take Rihoko away from her mother. They are caught and Rihoko is taken away. Meanwhile, Masane is attacked by an advanced weapon that can disguise itself as a human being. When faced with the danger, a strange light emits from her wrist and she transforms into a powerful being. She becomes involved in a power struggle between powerful organizations, with her at the center of their attention because she holds the greatest power of them all, the legendary Witchblade.






Six years after the mysterious destruction of Tokyo, Masane Amaha returns to the city along with her daughter Rihoko in hopes of a better life and to avoid the NSWF who are trying to take Rihoko away from her. The NSWF quickly catches up with them and proceeds to separate the two. In an attempt to rescue her daughter, Masane finds herself in jail where she is attacked by a monster. She transforms awakening the Witchblade.
After transforming, Masane is captured and used as a test subject. During her time with her captors, she learns about the history and powers of the Witchblade. Meanwhile, Rihoko travels around looking for her along with a male reporter, Yuusuke.